Chuck Mazoujian was educated at the Pratt Institute, where he graduated in 1939. He joined the Eisner/Iger Shop in 1939 and did comic book art on features for Fiction House ('Captain Terry Thunder'), Novelty and Quality Comics ('Jack and Jill', 'Mr. Zero', 'Quicksilver', 'Sally O'Neil', 'Samar', 'Z-11'). In 1940-41 he did art on the 'Lady Luck' Sunday page for Register and Tribune Syndicate. Mazoujian modeled the character after his fiance, then Edna Monson, who wore a stylish green hat.
After World War II, Mazoujian returned to New York to teach painting and figure drawing at the Pratt Institute night school. He did freelance book illustrations and commissioned paintings. During the 1960s he worked for Oglivy & Mather Advertising. He was a longtime member of the Society of Illustrators in NY and actively participated in the US Air Force art program. Charles Mazoujian passed away in Sacramento, California, in January 2011.